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TTFD: The Superior Form of Thiamine for Enhanced Energy, Brainpower, and Overall Health


Vitamin B1, also known as thiamine, is a crucial nutrient that plays a vital role in the body’s energy production, cognitive function, and overall well-being. As Health by Principle prepares to launch a new B1 product, it is essential to understand the unique benefits of thiamine and its more bioavailable form, TTFD (thiamine tetrahydrofurfuryl disulfide).  


Understanding Thiamine (Vitamin B1) 

Thiamine is a water-soluble vitamin that is essential for energy metabolism, nerve function, and cognitive health. The Recommended Daily Allowance (RDA) for thiamine is 1.2 mg for adult males and 1.1 mg for adult females. However, the typical forms of thiamine, such as thiamine hydrochloride (HCL), have limitations in their bioavailability. The human body requires transporters to absorb thiamine HCL effectively, which can result in limited cellular uptake. 


Introducing TTFD: A Superior Form of Thiamine 

TTFD is a fat-soluble form of thiamine that offers superior absorption and bioavailability compared to thiamine HCL. Unlike its water-soluble counterpart, TTFD can cross cellular membranes without the need for transporters, ensuring that a higher amount of thiamine is delivered to the cells. 


Key Benefits of TTFD 

Highly Bioavailable: TTFD’s fat-soluble nature allows it to be readily absorbed by the body, ensuring maximum effectiveness. 
    Crosses the Blood-Brain Barrier: TTFD is the only form of thiamine that can cross the blood-brain barrier, promoting cognitive health and supporting brain function. A 2018 study with rat test subjects showed TTFD increases voluntary activity and dopamine release in the prefrontal cortex, highlighting its role in enhancing brain function
      Supports Nutrient Metabolism: Thiamine is essential for the metabolism of carbohydrates, fats, and proteins, helping to convert food into energy. 
        Promotes Mitochondrial Health: TTFD supports mitochondrial function, the powerhouse of the cells, enhancing energy production and overall cellular health. 
          Reduces Oxidative Stress: Thiamine has antioxidant properties that help suppress oxidative stress, protecting cells from damage. 
            Improves Memory and Sleep: Thiamine’s role in neurotransmitter synthesis can improve memory and promote better sleep quality. 
              Reduces Anxiety: By supporting nervous system health, thiamine can help reduce symptoms of anxiety.

              Thiamine Deficiency and Factors Affecting Absorption 

              Thiamine deficiency can lead to several health issues, including beriberi, Wernicke-Korsakoff syndrome, and other neurological disorders. Factors such as alcohol consumption, caffeine, smoking, and certain medications can deplete thiamine levels in the body, making supplementation crucial for nearly all individuals. 


              TTFD in Research 

              Studies have shown that TTFD is effective in treating thiamine deficiencies and associated conditions. For instance, Sambon, Wins, and Bettendorff (2021) published a study highlighting TTFD’s ability to cross the blood-brain barrier and support cognitive health. 


              How We Created Our Formula and Why It’s the Best B1 Supplement

              Our B1 supplement is formulated with TTFD for its superior absorption and ability to cross the blood-brain barrier, ensuring maximum effectiveness. We included Methylfolate to support DNA synthesis and repair, and Vitamin C for its antioxidant properties and immune support. The Methylfolate is necessary for the absorption  and Vitamin C boosts the effectiveness of Thiamine. This combination sets our product apart from all others in the market by providing comprehensive support for energy production, cognitive function, and overall health.




              Biro, A., Gál, F., Hegedűs, C., Batta, G., Cziáky, Z., Peitl, B., Stündl, L., Gyémánt, G., & Remenyik, J. (2018). Isolation of allithiamine from Hungarian red sweet pepper seed (Capsicum annuum L.). Heliyon, 4(12), e00997. https://doi.org/10.1016/j.heliyon.2018.e00997. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288420/

              Foley, E. (2021). 5 Surprising Benefits of B Vitamins. Health by Principle. Retrieved from https://www.healthbyprinciple.com/blogs/news/5-surprising-benefits-of-b-vitamins?_pos=2&_sid=ee9038ee7&_ss=r

              Iwata, H., Matsuda, T., Maeda, S., & Baba, A. (1978). Stimulation of thiamine diphosphate activity by ascorbic acid in rat brain microsomes. Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University. Available online January 13, 2003.

              Saiki, M., Matsui, T., Soya, M., Kashibe, T., Shima, T., Shimizu, T., Naruto, T., Kitayoshi, T., Akimoto, K., Ninomiya, S., & Soya, H. (2018). Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex. Scientific Reports, 8, 10469. https://doi.org/10.1038/s41598-018-28462-2. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041333/

              Sambon, M., Wins, P., & Bettendorff, L. (2021). Neuroprotective effects of thiamine and precursors with higher bioavailability: Focus on benfotiamine and dibenzoylthiamine. International Journal of Molecular Sciences, 22(11), 5418. https://doi.org/10.3390/ijms22115418. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196556/

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