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 Women are nearly twice as likely as men to develop Alzheimer's disease over their lifetime and the reason goes deeper than longevity. Research now links magnesium deficiency to brain shrinkage, neuroinflammation, and accelerated cognitive aging, with the protective effects of higher intake showing up most strongly in women. Here is what the science says, why the menopausal transition is a critical window, and what consistent daily magnesium actually does inside the aging brain.