Mental fatigue is a particular and multifaceted challenge for migraine sufferers. Studies have found that mental fatigue contributes to migraines, migraines contribute to mental fatigue, and both contribute to depression.
Migraine and depression are deeply intertwined partly thanks to similar pathways within the brain. Even though they are distinct conditions - migraines being a neurological disorder and depression a mood disorder - they are so connected that they can both have an impact on each other.